DNA Binding Motif

						

			
Accessions: E2F3_ONECUT2_1 (HumanTF2 1.0), UN0492.1 (JASPAR 2024)

			
Names: E2F3_ONECUT2, E2F3::ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 18
Consensus: wdsGCGCsmwTATyGAyy
Weblogo: 
PSSM: P0      A      C      G      T
01   1424    463    732   1300      w
02   1113    356   1431   1018      d
03    467   1776   2142    610      s
04      0    269   3918      2      G
05     19   3918     23     22      C
06      0     11   3918     13      G
07      2   3918    132     27      C
08    902   2099   1820    428      s
09   1402   1352    376    788      m
10   1143    392    777   1606      w
11    839     77     56   2946      T
12   3918     20     22     40      A
13     50     35      9   3918      T
14    106   3918    157   1842      y
15     26     51   3918     28      G
16   3918     16     43      0      A
17    253   1468    225   2450      y
18    563   1058    671   1627      y
Type: Heterodimer
Binding TFs: ONECUT2_TF2 (Homeobox domain, CUT domain)
E2F3_TF1 (E2F/DP family winged-helix DNA-binding domain)
ONECUT2_Full (Homeobox domain, CUT domain)
O95948 (Homeobox domain, CUT domain)
O95948
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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