Transcription Factor

Accessions: E2F3_TF1 (HumanTF2 1.0), E2F3 (HT-SELEX2 May2017)
Names: E2F-3, E2F3, E2F3_HUMAN, Transcription factor E2F3, ENSG00000112242
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: O00716
Notes: Ensembl ID: ENSG00000112242; Construct type: TF1(SBP); TF family: E2F; Clone source: Jolma et al. 2013, TF family: E2F experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: E2F experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3
Length: 109
Pfam Domains: 24-89 E2F/DP family winged-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 GKGRAALRSPDSPKTPKSPSEKTRYDTSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQ 60
61 KRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQGLSKEV
Interface Residues: 24, 60, 61, 62, 63, 65
3D-footprint Homologues: 4yo2_A, 1cf7_A, 1cf7_B
Binding Motifs: E2F3_DRGX sGCGCTAATTks
E2F3_EOMES argYGykAtGGCGCstTmrCrcyt
E2F3_FOXI1 tGACACCGCGCCCaC
E2F3_FOXO6_1 gaaTGACACGCGCCCmc
E2F3_FOXO6_2 gaaTGACACcGCGCCCac
E2F3_HES7 wwdsGCGCsmwyggCrCGyGbc
E2F3_ONECUT2_1 wdsGCGCsmwTATyGAyy
E2F3_ONECUT2_2 wdsGCGCshwwTATCGAyy
E2F3_TBX21_1 agGTGtsAdgGCGCst
E2F3_TBX21_2 rgGTGykAwgGCGCstTsdCrcg
E2F3_TBX21_2_3 agGtGtgAatsGCGCsT
E2F3_2 rWTTTGGCGCCAAAWy
E2F3_methyl_1 rTTTTGGCGCCAAAAy
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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