DNA Binding Motif

						

			
Accessions: E2F3_DRGX (HumanTF2 1.0), UN0491.1 (JASPAR 2024)

			
Names: E2F3_DRGX, E2F3::DRGX
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 12
Consensus: sGCGCTAATTks
Weblogo: 
PSSM: P0      A      C      G      T
01    128    544    750    150      s
02      5     75   1293      8      G
03     26   1293      1     19      C
04      5      0   1293      4      G
05      3   1293    109     21      C
06     13    337     28   1293      T
07   1293     49     38      0      A
08   1293      0      2     18      A
09     29      0     19   1293      T
10     26     20     58   1293      T
11    325    176    829    464      k
12    196    450    373    275      s
Type: Heterodimer
Binding TFs: DRGX_TF2 (Homeobox domain)
O00716 (E2F/DP family winged-helix DNA-binding domain)
E2F3_TF1 (E2F/DP family winged-helix DNA-binding domain)
O00716
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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