DNA Binding Motif

						

			
Accessions: E2F3_HES7 (HumanTF2 1.0)

			
Names: E2F3_HES7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 22
Consensus: wwdsGCGCsmwyggCrCGyGbc
Weblogo: 
PSSM: P0      A      C      G      T
01    209    157    160    239      w
02    282     87    141    255      w
03    224     74    200    268      d
04     96    217    376     77      s
05     29    117    765     15      G
06     15    765     14     19      C
07     17     14    765     19      G
08      1    765     75     29      C
09     82    461    305    129      s
10    254    221    100    191      m
11    250    145     85    285      w
12    170    228    167    200      y
13    143    155    345    123      g
14    167    186    349     63      g
15     11    765      2     14      C
16    765     38    575    109      r
17      3    765      9      9      C
18     16     12    765      7      G
19    111    432     41    765      y
20      7     18    765     45      G
21     76    285    202    202      b
22    129    287    182    168      c
Type: Heterodimer
Binding TFs: HES7_TF2 (Helix-loop-helix DNA-binding domain)
E2F3_TF1 (E2F/DP family winged-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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