DNA Binding Motif

						

			
Accessions: E2F3_2 (HT-SELEX2 May2017), MA0469.3 (JASPAR 2024)

			
Names: E2F3
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 16
Consensus: rWTTTGGCGCCAAAWy
Weblogo: 
PSSM: P0      A      C      G      T
01  11774   2813   8684   6153      r
02   9758    153    336  25118      W
03   4706     81     83  28522      T
04   2828    320    109  27783      T
05   2537     98   3968  27496      T
06     72   3846  29311      0      G
07     11      0  29421     12      G
08     17  29393      9     24      C
09     26     14  29386     25      G
10     14  29427      0      8      C
11      0  29368   3755     71      C
12  27525   3862     78   2530      A
13  27860    113    272   2677      A
14  28547     80     92   4552      A
15  25059    397    114   9732      W
16   6056   8775   2756  11838      y
Type: Heterodimer
Binding TFs: O00716 (E2F/DP family winged-helix DNA-binding domain)
E2F3 (E2F/DP family winged-helix DNA-binding domain)
O00716
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Rabinovich A, Jin VX, Rabinovich R, Xu X, Farnham PJ. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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