Transcription Factor

						

			
Accessions: E2F3_HUMAN (HOCOMOCO 10), O00716 (JASPAR 2024)

			
Names: E2F-3, E2F3_HUMAN, Transcription factor E2F3
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O00716
Length: 465
Pfam Domains:   178-243 E2F/DP family winged-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQI   60
  61 LTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALG  120
 121 RGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYD  180
 181 TSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQ  240
 241 WMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVT  300
 301 YQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHSP  360
 361 MKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEG  420
 421 PFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS
Interface Residues: 156, 158, 178, 214, 215, 216, 217, 219
3D-footprint Homologues: 7jn3_E, 1cf7_A, 4yo2_A, 1cf7_B
Binding Motifs: MA0469.2 aAAAAkGGCGCCawWTTt
UN0491.1 sGCGCTAATTks
MA0469.3 rWTTTGGCGCCAAAWy
E2F3_HUMAN.H10MO.B|M01088 ssCGCsaMAc
MA0469.4 WTTTGGCGCCAAAW
UN0491.2 sGCGCTAATT
			
Publications: Rabinovich A, Jin VX, Rabinovich R, Xu X, Farnham PJ. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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