DNA Binding Motif

						

			
Accessions: ETV2_ONECUT2_2_3_4_5 (HumanTF2 1.0)

			
Names: ETV2_ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 21
Consensus: rcCGGAAryrrgsrATCrATr
Weblogo: 
PSSM: P0      A      C      G      T
01   1585    184    889    344      r
02    886   2474   1090    212      c
03    401   2474     29     10      C
04      8      3   2474     12      G
05      0      1   2474     20      G
06   2474      5      0      0      A
07   2474    173      0    827      A
08    801    223   1407     43      r
09    292    790    214   1179      y
10    704    510    843    418      r
11    701    592    812    370      r
12    602    567    710    596      g
13    371    844    642    617      s
14    981    162   1493    267      r
15   2474     66    870    208      A
16      0     22      0   2474      T
17      6   2474      4     36      C
18    836     29   1639     33      r
19   2474     16     51    181      A
20    182     73     11   2474      T
21   1065    224    717    468      r
Type: Heterodimer
Binding TFs: ONECUT2_TF2 (Homeobox domain, CUT domain)
ETV2_TF1 (Ets-domain)
ONECUT2_Full (Homeobox domain, CUT domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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