Transcription Factor
| Accessions: | PITX1_DBD (HumanTF 1.0), PITX1_TF1 (HumanTF2 1.0), PITX1_TF2 (HumanTF2 1.0), PITX1 (HT-SELEX2 May2017) |
| Names: | Hindlimb-expressed homeobox protein backfoot, Homeobox protein PITX1, Paired-like homeodomain transcription factor 1, Pituitary homeobox 1, PITX1, PITX1_HUMAN, ENSG00000069011 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P78337 |
| Notes: | Ensembl ID: ENSG00000069011; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, Ensembl ID: ENSG00000069011; Construct type: TF1(SBP); TF family: Homeodomain; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000069011; Construct type: TF2(3xFLAG); TF family: Homeodomain; Clone source: Jolma et al. 2013, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 112 |
| Pfam Domains: | 26-82 Homeobox domain |
| Sequence: (in bold interface residues) | 1 KGPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAV 60 61 WTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYA |
| Interface Residues: | 24, 25, 26, 27, 28, 29, 67, 68, 70, 71, 74, 75, 78, 79, 82, 83 |
| 3D-footprint Homologues: | 1qum_A, 2h1k_B, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1ig7_A, 5zfz_A, 1puf_A, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 1jgg_B, 2ld5_A, 3a01_E, 7psx_B, 5hod_A, 1puf_B, 1au7_A, 2hdd_A, 7q3o_C, 3rkq_B, 2r5y_A, 6es3_K, 1b72_A, 4xrs_G, 2hos_A, 5flv_I, 3l1p_A, 5zjt_E, 5jlw_D, 4j19_B, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 1mnm_C, 1k61_B, 4qtr_D, 1o4x_A, 4cyc_A, 1le8_B, 1du0_A, 8g87_X |
| Binding Motifs: | PITX1_DBD myTAATCCc ARNTL_PITX1_1 CACGTGmkmGgmTTat ARNTL_PITX1_2 rkCACGTGhvagggmTTAw CUX1_PITX1 gGATTAwstkATCrATr ERF_PITX1_1 rccGGAwGydgrgmTta ERF_PITX1_2 kscGGAwryrrkggmTta ETV2_PITX1 rsCGGAArtrrrGGmTTAg FOXJ2_PITX1_1 yTAATCCcdamAAcA FOXJ2_PITX1_2 TAAAcaGGATTA GCM1_PITX1_1 GGaTTAsssgggkkrTGCGGG GCM1_PITX1_2 GgATTAkrskgbrTGcGGG GCM1_PITX1_2_3 GGaTTAwggsGrTGCGGG GCM2_PITX1_1 rTrcgGGyGGATTA GCM2_PITX1_2 rTrcGGGsGATTAr HOXB2_PITX1_1 TaATkaygGGATTA HOXB2_PITX1_2 taATkrgGGATTA HOXB2_PITX1_2_3 taAtkrssrmGGATTA HOXB2_PITX1_2_3_4 TaATkrsrrGGATTA MGA_PITX1 rgGTGyTAAkcyg PITX1_EOMES_1 GGATTArcrgGTGtgr PITX1_EOMES_2 rgGTGTkAarkrGGATTA PITX1_FIGLA TAATCCsywmCAssTG PITX1_HES7_1 rCwCGTGksGGATTA PITX1_HES7_2 rCrcGtGgrkGGATTA PITX1_HES7_2_3 rgCrCGTGbkrsGGATTA PITX1_HOXA3 taATkrgkgkgGATTA PITX1_TBX21 AGGTGyGAArGGATTA TEAD4_PITX1_1 rCATwcywraGGATTA TEAD4_PITX1_2 rCATtccrtasGgATTA TEAD4_PITX1_2_3 rCATwCywrhvyTAATCy TEAD4_PITX1_2_3_4 rCATwCCtmvyTAATCC TEAD4_PITX1_2_3_4_5 rCATwCCdyacTAATCC PITX1_2 yTAATCCc PITX1_4 yTAATCCc PITX1_methyl_1 yTAAKCCr PITX1_methyl_3 yTAATCCc |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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