DNA Binding Motif

						

			
Accessions: GCM2_PITX1_2 (HumanTF2 1.0), UN0554.1 (JASPAR 2024)

			
Names: GCM2_PITX1, GCM2::PITX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: rTrcGGGsGATTAr
Weblogo: 
PSSM: P0      A      C      G      T
01   4134   1557   2538    702      r
02    766    996    646   6672      T
03   2033    719   4639     18      r
04   3425   6672   1641   2618      c
05   1538     17   6672    740      G
06      0      0   6672      0      G
07      7     12   6672     23      G
08    588   3401   3271    766      s
09     53     74   6672    250      G
10   6672   1562    149    128      A
11      0    146     44   6672      T
12    670    585    133   6672      T
13   6672    205    523   1556      A
14   1756   1037   2372   1507      r
Type: Heterodimer
Binding TFs: GCM2_TF1 (GCM motif protein)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
P78337 (Homeobox domain, OAR domain)
P78337
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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