DNA Binding Motif

						

			
Accessions: ETV2_PITX1 (HumanTF2 1.0)

			
Names: ETV2_PITX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 19
Consensus: rsCGGAArtrrrGGmTTAg
Weblogo: 
PSSM: P0      A      C      G      T
01    905    108    701    218      r
02    246    992    614     90      s
03    456   1606     33     10      C
04      0      7   1606      3      G
05      0      0   1606      0      G
06   1606      0      5     18      A
07   1606     81      8    404      A
08    445     71   1065     24      r
09    179    379    271    777      t
10    449    361    544    252      r
11    582    255    501    268      r
12    491    300    516    299      r
13    532     80   1606     90      G
14    129     64   1606    166      G
15   1094    512     25     30      m
16      2     16     35   1606      T
17     95    119     47   1606      T
18   1606     29     56    199      A
19    380    399    573    253      g
Type: Heterodimer
Binding TFs: PITX1_TF1 / PITX1_TF2 (Homeobox domain)
ETV2_TF1 (Ets-domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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