DNA Binding Motif

						

			
Accessions: FOXJ2_PITX1_2 (HumanTF2 1.0), UN0534.1 (JASPAR 2024)

			
Names: FOXJ2_PITX1, FOXJ2::PITX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 12
Consensus: TAAAcaGGATTA
Weblogo: 
PSSM: P0      A      C      G      T
01     48     23      0    189      T
02    189      3      0     58      A
03    189      0      8     28      A
04    189      3     12     28      A
05     23    189      6     63      c
06    189     29     16     60      a
07     26      0    189     47      G
08     41      7    189      0      G
09    189     24      9      0      A
10      0      0      0    189      T
11      4     19      2    189      T
12    189     16     12     11      A
Type: Heterodimer
Binding TFs: Q9P0K8 (Fork head domain)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
FOXJ2_TF1 (Fork head domain)
Q9P0K8
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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