DNA Binding Motif

						

			
Accessions: PITX1_HES7_2_3 (HumanTF2 1.0)

			
Names: PITX1_HES7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 18
Consensus: rgCrCGTGbkrsGGATTA
Weblogo: 
PSSM: P0      A      C      G      T
01     94     56    135     18      r
02     19     60    185     39      g
03     68    303     61      4      C
04    168      4    134     37      r
05     20    303     20     27      C
06     13     13    303      4      G
07     19     38     54    303      T
08      0     25    303      7      G
09     14     98     90    101      b
10     30     54    102    116      k
11    116      0    118     74      r
12     22    102    125     54      s
13     82      0    303      6      G
14     64      0    303     40      G
15    303      1     14      8      A
16      9      0      0    303      T
17      0     14     31    303      T
18    303      7     10     44      A
Type: Heterodimer
Binding TFs: HES7_TF2 (Helix-loop-helix DNA-binding domain)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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