DNA Binding Motif

						

			
Accessions: PITX1_HES7_2 (HumanTF2 1.0)

			
Names: PITX1_HES7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 16
Consensus: rCrcGtGgrkGGATTA
Weblogo: 
PSSM: P0      A      C      G      T
01     78      0     87     42      r
02     24    207      3     15      C
03    142     11     64      7      r
04     14    207     44     74      c
05     45      0    207      0      G
06     36     75     32    207      t
07      0     17    207     15      G
08     16     35    106     50      g
09     67     35     74     32      r
10      0     35     90     82      k
11     34     12    207     10      G
12      0     21    207      0      G
13    207      0     22     11      A
14      0      0     24    207      T
15     23     13      0    207      T
16    207      1      0     15      A
Type: Heterodimer
Binding TFs: HES7_TF2 (Helix-loop-helix DNA-binding domain)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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