DNA Binding Motif

						

			
Accessions: PITX1_HES7_1 (HumanTF2 1.0), UN0575.1 (JASPAR 2024)

			
Names: PITX1_HES7, PITX1::HES7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: rCwCGTGksGGATTA
Weblogo: 
PSSM: P0      A      C      G      T
01     87     19     49      0      r
02      6    152      0      0      C
03    152      2     37     70      w
04      4    152      0      6      C
05      9      4    152      0      G
06      3     19     36    152      T
07      0     11    152      9      G
08     22     18     68     45      k
09     35     43     62     13      s
10     17     10    152     37      G
11     10      0    152      5      G
12    152      0      0     15      A
13     14      3      0    152      T
14     12      3      7    152      T
15    152      0      0      4      A
Type: Heterodimer
Binding TFs: HES7_TF2 (Helix-loop-helix DNA-binding domain)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
Q9BYE0 (Helix-loop-helix DNA-binding domain)
Q9BYE0
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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