DNA Binding Motif

						

			
Accessions: ARNTL_PITX1_1 (HumanTF2 1.0)

			
Names: ARNTL_PITX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 16
Consensus: CACGTGmkmGgmTTat
Weblogo: 
PSSM: P0      A      C      G      T
01      0   2168      1      0      C
02   2168     37     43      6      A
03      4   2168      1      0      C
04      1      0   2168      8      G
05      0      3     26   2168      T
06      0      0   2168     86      G
07    642   1252     78    195      m
08    304    215    804    845      k
09    571    862    374    362      m
10    333    272   1835     85      G
11    561    123   2168    664      g
12   2168   1044    324     37      m
13    139     27    175   2168      T
14    159    593    112   2168      T
15   2168    250    336    491      a
16    459    446    166   1097      t
Type: Heterodimer
Binding TFs: PITX1_TF1 / PITX1_TF2 (Homeobox domain)
ARNTL_TF1 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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