DNA Binding Motif

Accessions: GCM1_PITX1_1 (HumanTF2 1.0)
Names: GCM1_PITX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 21
Consensus: GGaTTAsssgggkkrTGCGGG
Weblogo:
PSSM: P0 A C G T
01 0 9 101 20 G
02 0 13 101 16 G
03 101 38 22 9 a
04 15 0 0 101 T
05 22 6 14 101 T
06 101 0 5 2 A
07 24 26 47 4 s
08 12 32 51 6 s
09 23 27 32 19 s
10 17 18 43 23 g
11 16 21 49 15 g
12 18 3 59 21 g
13 18 23 26 34 k
14 13 18 32 38 k
15 48 23 33 0 r
16 3 0 0 101 T
17 0 1 101 0 G
18 0 101 32 9 C
19 9 9 101 11 G
20 7 1 101 2 G
21 2 2 101 2 G
Type: Heterodimer
Binding TFs: GCM1_TF1 (GCM motif protein)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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