Transcription Factor
| Accessions: | GCM1_DBD (HumanTF 1.0), GCM1_TF1 (HumanTF2 1.0), GCM1 (HT-SELEX2 May2017) |
| Names: | Chorion-specific transcription factor GCMa, GCM motif protein 1, GCM1, GCM1_HUMAN, Glial cells missing homolog 1, hGCMa, ENSG00000137270 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q9NP62 |
| Notes: | Ensembl ID: ENSG00000137270; DNA-binding domain sequence; TF family: GCM; Clone source: Gene synthesis, Ensembl ID: ENSG00000137270; Construct type: TF1(SBP); TF family: GCM; Clone source: Jolma et al. 2013, TF family: GCM experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: GCM experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 183 |
| Pfam Domains: | 29-169 GCM motif protein |
| Sequence: (in bold interface residues) | 1 MEPDDFDSEDKEILSWDINDVKLPQNVKKTDWFQEWPDSYAKHIYSSEDKNAQRHLSSWA 60 61 MRNTNNHNSRILKKSCLGVVVCGRDCLAEEGRKIYLRPAICDKARQKQQRKRCPNCDGPL 120 121 KLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAMKKVNTAPSSVS 180 181 LSL |
| Interface Residues: | 63, 64, 65, 67, 100 |
| 3D-footprint Homologues: | 1odh_A |
| Binding Motifs: | GCM1_DBD yATGCGGGTa GCM1_CEBPB_1 ATGcGGGyrkrTTGCGYAAy GCM1_CEBPB_2 rTGcGGGyrgrkrTTGCGYAAy GCM1_CEBPB_2_3 rTRcGGGyrgkrTTGCGYAAy GCM1_ELF1_1 rkGcGGGCGGAaGtr GCM1_ELF1_2 kvCGGAArTGckGGt GCM1_ELF1_2_3 crCCCrCACGGAAGtr GCM1_ELK1_1 ATryGGGCGGAAmCGGAwsta GCM1_ELK1_2 rtGcGGGCGGAAGkg GCM1_ELK1_2_3 rtGcGGGCGGAAGkg GCM1_ELK3_1 aCCCGCArCCGGAAGy GCM1_ELK3_2 rTGCGGGCGGAAGtg GCM1_ERG rTGCGGGCGGaarkg GCM1_ETV1 rtrsGGGCGGAwGkk GCM1_ETV4 aTrCGGGCGGAAGyr GCM1_ETV7_1 atrmGGGCGGAArydyTTCCbby GCM1_ETV7_2 mTrmGGGCGGAaGtgkdtCCssy GCM1_FIGLA_1 CAssTGsaCCCgCAy GCM1_FIGLA_2 CAssTGkkrbkkkrksrTGcGGG GCM1_FIGLA_2_3 CAssTGkkgsgkkggrTGcGGG GCM1_FIGLA_2_3_4 CAssTGkdrbgkgrTGcGGG GCM1_FIGLA_2_3_4_5 CAssTGkkgggsrTGcGGG GCM1_FIGLA_2_3_4_5_6 CAssTGkaamtaCCmgCAy GCM1_FIGLA_2_3_4_5_6_7 CAssTGkkcsmgrskcATGCGGG GCM1_FIGLA_2_3_4_5_6_7_8 CASsTGykmkkrkvrTGCGGG GCM1_FIGLA_2_3_4_5_6_7_8_9 CAssTGkkgbkkbaTRCGGG GCM1_FIGLA_2_3_4_5_6_7_8_9_10 CAssTGkhgbkrrTRcGGG GCM1_FOXI1_1 rTGTTGATrcGGGy GCM1_FOXI1_2 GTAAATAmGGGyr GCM1_FOXI1_2_3 ryGTMAATAvGGGyr GCM1_FOXI1_2_3_4 RTmAACATrcGGGy GCM1_FOXI1_2_3_4_5 TGTTGaTrcGGGt GCM1_FOXO1_1 GtmAATAmGGGyrg GCM1_FOXO1_2 gTmAATAmGGGyas GCM1_HOXA13 rTGcGGGTmaTaAa GCM1_HOXA2 rTrsGGGygTrATkr GCM1_HOXB13_1 rTGcGGGTmATaAaw GCM1_HOXB13_2 aCCCsCAcCmATAAM GCM1_HOXB13_2_3 rCCCgyAysymrTAAm GCM1_HOXB13_2_3_4 rTGcGGGTmATAAAm GCM1_MAX_1 rbCACGTGsrTGckGGyr GCM1_MAX_2 rgCACGTGkkyvsgggcgrTGCGGGyrs GCM1_MAX_2_3 aTGCGGGyrgsgmgCACGTGg GCM1_MAX_2_3_4 CACGTGgwTgcgGGy GCM1_MAX_2_3_4_5 rgCACGTGsyyrvkggssrTGCGGGTrs GCM1_MAX_2_3_4_5_6 aTGCGGGyrggrrgCACGTGs GCM1_NHLH1_1 gCAGCTGykwsmsbrtGcgGG GCM1_NHLH1_2 gCAGsTGykgyysrTrmGGG GCM1_ONECUT2_1 rTGcGGGwAATCGATr GCM1_ONECUT2_2 rTGcGGGaAATCGATr GCM1_PITX1_1 GGaTTAsssgggkkrTGCGGG GCM1_PITX1_2 GgATTAkrskgbrTGcGGG GCM1_PITX1_2_3 GGaTTAwggsGrTGCGGG GCM1_SOX2 ATrCGGGyvyATTGTty GCM1_SPDEF_1 rTrsgGGCGGAtgyrywTCCGgs GCM1_SPDEF_2 rTGvkGGCGGAygbsrsaTCCGgb GCM1_SPDEF_2_3 rTgmkGGcGGAtg GCM1_SPDEF_2_3_4 rTrmkGGCGGAtgykgsdTCCGssy GCM1_SPDEF_2_3_4_5 rtgsGGGCGGAwgyrydTCCgkkt GCM1_TBX21_1 aGGTGtsrTGcGGGyk GCM1_TBX21_2 rgGTGtkAhyyhmhtkTmrCATrcGGGy GCM1_2 rTGcGGGtr GCM1_methyl_1 ATrrkGGyr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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