DNA Binding Motif

						

			
Accessions: PITX1_4 (HT-SELEX2 May2017), MA0682.2 (JASPAR 2024)

			
Names: PITX1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 8
Consensus: yTAATCCc
Weblogo: 
PSSM: P0      A      C      G      T
01   2898   6099   2382   4432      y
02      0      0      0  10531      T
03  10531      0      0      0      A
04  10531      0      0      0      A
05      0      0   1039  10531      T
06    143  10531      0    141      C
07     68  10531    134    547      C
08   2348   4194   1876   2113      c
Type: Heterodimer
Binding TFs: PITX1 (Homeobox domain)
P78337 (Homeobox domain, OAR domain)
P78337
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Lamonerie T., Tremblay J. J., Lanctot C., Therrien M., Gauthier Y., Drouin J. Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev. 10:1284-1295 (1996). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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