DNA Binding Motif

						

			
Accessions: CUX1_PITX1 (HumanTF2 1.0)

			
Names: CUX1_PITX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 17
Consensus: gGATTAwstkATCrATr
Weblogo: 
PSSM: P0      A      C      G      T
01    579    360   2302    323      g
02    237    156   2302    263      G
03   2302    631     23    192      A
04     27     24      1   2302      T
05     87    216      7   2302      T
06   2302     29     47    155      A
07    870    509    288    635      w
08    468    797    829    209      s
09    320    428    546   1008      t
10    480    241    809    772      k
11   2302    104    217    231      A
12     18     26     15   2302      T
13     11   2302      3    108      C
14   1102     51   1200     41      r
15   2302     13     18     82      A
16    262      6      5   2302      T
17   1007    338    648    308      r
Type: Heterodimer
Binding TFs: CUX1_TF1 (Homeobox domain, CUT domain, Homeobox KN domain)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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