DNA Binding Motif

						

			
Accessions: PITX1_TBX21 (HumanTF2 1.0), UN0576.1 (JASPAR 2024)

			
Names: PITX1_TBX21, PITX1::TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: AGGTGyGAArGGATTA
Weblogo: 
PSSM: P0      A      C      G      T
01    341      4     90     13      A
02     60     15    342     68      G
03      0      0    399      0      G
04      6     73     35    400      T
05      4      0    406      8      G
06     69    127     13    196      y
07     31     38    342     69      G
08    388      0     50      3      A
09    371     13     84     39      A
10    178     27    212     14      r
11     55      2    383      6      G
12     20      0    401      1      G
13    396      0     23      6      A
14      7      0     17    396      T
15     24      4      0    398      T
16    407      0      8     12      A
Type: Heterodimer
Binding TFs: PITX1_TF1 / PITX1_TF2 (Homeobox domain)
TBX21_TF2 (T-box)
Q9UL17 (T-box)
Q9UL17
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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