Transcription Factor
| Accessions: | TBX21_DBD (HumanTF 1.0), TBX21_TF2 (HumanTF2 1.0), TBX21 (HT-SELEX2 May2017) |
| Names: | T-box protein 21, T-box transcription factor TBX21, T-cell-specific T-box transcription factor T-bet, TBX21, TBX21_HUMAN, Transcription factor TBLYM, ENSG00000073861 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q9UL17 |
| Notes: | Ensembl ID: ENSG00000073861; DNA-binding domain sequence; TF family: T-box; Clone source: Gene synthesis, Ensembl ID: ENSG00000073861; Construct type: TF2(3xFLAG); TF family: Tbox; Clone source: Jolma et al. 2013, TF family: T_box experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: T_box experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 222 |
| Pfam Domains: | 19-207 T-box |
| Sequence: (in bold interface residues) | 1 PREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPT 60 61 SHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFG 120 121 KLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFI 180 181 AVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSP |
| Interface Residues: | 44, 81, 83, 84, 86, 87, 183, 184, 200, 203, 204 |
| 3D-footprint Homologues: | 4a04_B, 1xbr_B, 5flv_I, 6f59_B, 2x6v_A, 1h6f_B, 2ram_A |
| Binding Motifs: | TBX21_DBD_1 gGTGTGAwwTcACACc TBX21_DBD_2 rAGGTGTGAa TBX21_DBD_3 TmACACcTydrAGGTGTGA ALX4_TBX21_1 rgGTGykAATwawmrtysrCAsykm ALX4_TBX21_2 AGGTGytAATwa CUX1_TBX21_1 kTcACACmyyrATCrATm CUX1_TBX21_2 tCACACCyrATa E2F3_TBX21_1 agGTGtsAdgGCGCst E2F3_TBX21_2 rgGTGykAwgGCGCstTsdCrcg E2F3_TBX21_2_3 agGtGtgAatsGCGCsT ELK1_TBX21_1 aaGGtGtgrmrkkkmkttmrCrcCGGAAGyg ELK1_TBX21_2 tcrCACCGGAAgyr ELK1_TBX21_2_3 agGTGykAaawwwwwtTmaCACMGGAart ELK1_TBX21_2_3_4 TmaCACmGGAwvhg ERF_TBX21_1 agGTGtgaagwrvkgktcaCrCCGGAArw ERF_TBX21_2 TmaCACCGGAAr ETV2_TBX21_1 gGTGTkAaarmkrkkTvwCRCmGGAwrk ETV2_TBX21_2 TmrCrCmGGAwry ETV2_TBX21_2_3 aCCGGAwryrmvmhyYmACACCTy ETV7_TBX21_1 mCCGGAAryvrahtTcaCRCct ETV7_TBX21_2 mCCGGAAryrmbhTCaCACcy FOXJ3_TBX21_1 arsyGtkRawarawAACAACACch FOXJ3_TBX21_2 wAACAACACct- GCM1_TBX21_1 aGGTGtsrTGcGGGyk GCM1_TBX21_2 rgGTGtkAhyyhmhtkTmrCATrcGGGy GCM2_TBX21_1 aGGTGTcrwGsGGGy GCM2_TBX21_2 ATGmGGGCTAGGTGtGA HOXB13_TBX21_1 AgGTGTGAttkmwWAAAc HOXB13_TBX21_2 ArGTGtkAmcwATAAA HOXB13_TBX21_2_3 rgGTGTgAatTtATkr HOXB2_TBX21_1 ragGTGyTAATkr HOXB2_TBX21_2 agGTGTkrrkmgymATTwrCAs HOXB2_TBX21_2_3 trAtkAgGTGykA HOXC10_TBX21 TmrCACyTmATWAA HOXD12_TBX21_1 agGTGtkArGTCGTAAA HOXD12_TBX21_2 rgGYGtkdkkcgkyktwmaCAssTmrTaAa HOXD12_TBX21_2_3 yvrCACsTCrTWAw MYBL1_TBX21 aGGTGTGACsGTTr PITX1_TBX21 AGGTGyGAArGGATTA POU2F1_TBX21_1 hgTGydrgmATATkmthaCAcc POU2F1_TBX21_2 wTATkCAGyGywa SOX6_TBX21_1 rgGTGtkryttwdksywTTGT SOX6_TBX21_2 rgGTGtkrwwdwdrACAATrg TEAD4_TBX21_1 arGTGTGAATwcy TEAD4_TBX21_2 aGGTGTkRmsdvtrgwATGy TBX21_2 rAGGTGTgAa TBX21_methyl_1 rAgGTGTgAa |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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