DNA Binding Motif

						

			
Accessions: PITX1_FIGLA (HumanTF2 1.0)

			
Names: PITX1_FIGLA
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 16
Consensus: TAATCCsywmCAssTG
Weblogo: 
PSSM: P0      A      C      G      T
01    415     82      0   1485      T
02   1485     66    285    125      A
03   1485      0     45     19      A
04    107     37    537   1485      T
05    159   1485    117     94      C
06    144   1485    125    401      C
07    187    555    397    346      s
08    256    387    194    648      y
09    450    278    136    621      w
10    601    429    142    313      m
11     18   1485      0     27      C
12   1485      4      3     33      A
13      8    791    694      4      s
14      5   1012    472      3      s
15     50     55      0   1485      T
16      0     20   1485     16      G
Type: Heterodimer
Binding TFs: FIGLA_TF2 (Helix-loop-helix DNA-binding domain)
PITX1_TF1 / PITX1_TF2 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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