DNA Binding Motif

						

			
Accessions: ARNTL_PITX1_2 (HumanTF2 1.0)

			
Names: ARNTL_PITX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 19
Consensus: rkCACGTGhvagggmTTAw
Weblogo: 
PSSM: P0      A      C      G      T
01   2247   1186   2365   1733      r
02   1175    175   3148   3033      k
03     89   7530      1      3      C
04   7530     93    116    122      A
05      0   7530      0    122      C
06    227     31   7530      0      G
07    108    876     47   7530      T
08     15      5   7530    240      G
09   2855   1987    600   2089      h
10   1885   2349   2024   1272      v
11   2922   1699   1164   1745      a
12   1759   1669   2319   1783      g
13   2139    863   5391   1709      g
14   1481   1101   7530   1243      g
15   4492   3039    369    534      m
16     35    323     65   7530      T
17   1258    931    616   7530      T
18   7530    405    778   1774      A
19   2595   1553   1003   2380      w
Type: Heterodimer
Binding TFs: PITX1_TF1 / PITX1_TF2 (Homeobox domain)
ARNTL_TF1 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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