Transcription Factor

Accessions: FOXI1_full (HumanTF 1.0), FOXI1_TF2 (HumanTF2 1.0)
Names: A8K811_HUMAN, cDNA FLJ76677, highly similar to Homo sapiens forkhead box I1, FOXI1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: A8K811
Notes: Ensembl ID: ENSG00000168269; Full protein sequence; TF family: Forkhead; Clone source: Megaman, Ensembl ID: ENSG00000168269; Construct type: TF2(3xFLAG); TF family: Forkhead; Clone source: Jolma et al. 2013
Length: 379
Pfam Domains: 123-218 Fork head domain
Sequence:
(in bold interface residues)
1 MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPN 60
61 PYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMK 120
121 LVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDC 180
181 FKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPV 240
241 DSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLV 300
301 TPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHF 360
361 YNSVNTSGVLYPREGTEV*
Interface Residues: 163, 166, 168, 169, 170, 172, 173, 174, 176, 177, 186, 193, 218
3D-footprint Homologues: 3l2c_A, 7vox_H, 2hdc_A, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 3qrf_G
Binding Motifs: FOXI1_full_1 GTAAACA
FOXI1_full_2 rTGTkTACGGTAAACAA
CUX1_FOXI1 rTmawCAcgmkrATCRATt
E2F3_FOXI1 tGACACCGCGCCCaC
ELK1_FOXI1_1 AsCGGAArTrTmAACAk
ELK1_FOXI1_2 rCCGGAAGsWmArCAk
ELK1_FOXI1_2_3 rmCGGAAGTTkw
ELK1_FOXI1_2_3_4 wGyTkmCGGAwGTk
ELK1_FOXI1_2_3_4_5 ammGGAAayrTAAAyA
ELK1_FOXI1_2_3_4_5_6 ammGGAAbrtAAACA
ERF_FOXI1_1 rcCGGAwGTtkwy
ERF_FOXI1_2 rtaaACmGGAArtr
ERF_FOXI1_2_3 trTtkmCGGAart
ETV2_FOXI1_1 sgtaaACAGGAwRyr
ETV2_FOXI1_2 rCCGGAAGTmwACA
ETV2_FOXI1_2_3 rcCGGAAryrtmmACAy
ETV2_FOXI1_2_3_4 rcCGGATGTTkw
ETV2_FOXI1_2_3_4_5 TGTtkmCGGAWGtg
ETV5_FOXI1_1 GtMAACMGGAwGy
ETV5_FOXI1_2 rsCGGAwGTkkw
ETV5_FOXI1_2_3 tGtkkmCGGAwGt
FLI1_FOXI1_1 GAAAACCGAAAM
FLI1_FOXI1_2 rcCGGAWGTTkay
FLI1_FOXI1_2_3 rtaAACAGGAwryd
FLI1_FOXI1_2_3_4 TGTtkmCGGAwrtg
GCM1_FOXI1_1 rTGTTGATrcGGGy
GCM1_FOXI1_2 GTAAATAmGGGyr
GCM1_FOXI1_2_3 ryGTMAATAvGGGyr
GCM1_FOXI1_2_3_4 RTmAACATrcGGGy
GCM1_FOXI1_2_3_4_5 TGTTGaTrcGGGt
GCM2_FOXI1_1 rTAAATAmGGGya
GCM2_FOXI1_2 TrTTkATrcGGGy
TEAD4_FOXI1_1 GGwATGyGtmmACa
TEAD4_FOXI1_2 rCATTCCryayhmygcmawmyrwmAACA
TEAD4_FOXI1_2_3 GCATwCCryrmmmwsyymmyrTmAACA
TEAD4_FOXI1_2_3_4 rCATTCCabmrmmavgrvmrtmmACA
TEAD4_FOXI1_2_3_4_5 rCaTtCCacmcysrmAgYGmmmaCA
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.