DNA Binding Motif

						

			
Accessions: ERF_FOXI1_2 (HumanTF2 1.0), MA1935.1 (JASPAR 2024)

			
Names: ERF_FOXI1, ERF::FOXI1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: rtaaACmGGAArtr
Weblogo: 
PSSM: P0      A      C      G      T
01    256    111    463     62      r
02    304    254    299    719      t
03    719    287    125    178      a
04    719    161    150    224      a
05    719     50    175     12      A
06     87    719    112     52      C
07    403    316     27      0      m
08     35     28    719      0      G
09      0     33    719     20      G
10    719      1      6     10      A
11    719     89      5    236      A
12    287     87    433     16      r
13    112    216    120    503      t
14    195    121    276    128      r
Type: Heterodimer
Binding TFs: Q12951 (Fork head domain)
FOXI1_TF2 (Fork head domain)
ERF_TF1 (Ets-domain)
Q12951
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB. Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions. Nat Commun 11:124 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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