DNA Binding Motif

						

			
Accessions: ETV2_FOXI1_1 (HumanTF2 1.0), MA1942.1 (JASPAR 2024)

			
Names: ETV2_FOXI1, ETV2::FOXI1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: sgtaaACAGGAwRyr
Weblogo: 
PSSM: P0      A      C      G      T
01    265    586    470    426      s
02    450    232   1298    114      g
03    446    453    527   1747      t
04   1322    426    175    150      a
05   1747    323    391    259      a
06   1747     55    183     37      A
07     38   1747     84     33      C
08   1359    388     14      0      A
09     14     30   1747     19      G
10     33      0   1747    105      G
11   1747     35      0     14      A
12   1747     84     18    755      w
13    469     20   1278      3      R
14    247    742    163   1005      y
15    488    204    710    344      r
Type: Heterodimer
Binding TFs: FOXI1_TF2 (Fork head domain)
ETV2_TF1 (Ets-domain)
Q3KNT2 (Ets-domain)
Q3KNT2
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


De Val S., Chi N. C., Meadows S. M., Minovitsky S., Anderson J. P., Harris I. S., Ehlers M. L., Agarwal P., Visel A., Xu S. M., Pennacchio L. A., Dubchak I., Krieg P. A., Stainier D. Y., Black B. L. Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors.. Cell 135:1053-1064 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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