Transcription Factor
| Accessions: | GCM2_DBD (HumanTF 1.0), GCM2_TF1 (HumanTF2 1.0) |
| Names: | Chorion-specific transcription factor GCMb, GCM motif protein 2, GCM2, GCM2_HUMAN, Glial cells missing homolog 2, hGCMb |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | O75603 |
| Notes: | Ensembl ID: ENSG00000124827; DNA-binding domain sequence; TF family: GCM; Clone source: Gene synthesis, Ensembl ID: ENSG00000124827; Construct type: TF1(SBP); TF family: GCM; Clone source: Jolma et al. 2013 |
| Length: | 189 |
| Pfam Domains: | 35-173 GCM motif protein |
| Sequence: (in bold interface residues) | 1 MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRH 60 61 LSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPN 120 121 CHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMA 180 181 SFYQPQKKR |
| Interface Residues: | 68, 69, 70, 72, 89, 93, 105 |
| 3D-footprint Homologues: | 1odh_A, 4hc9_A |
| Binding Motifs: | GCM2_DBD bATGCGGGyr GCM2_DLX2 rTrcGGGywadwtAATtr GCM2_DLX3_1 aTrcGGGywkwyttAATtr GCM2_DLX3_2 aTrcGGGywrkdtAAttr GCM2_DRGX_1 rTrsGGGtaATTag GCM2_DRGX_2 ATrcGGGytaaTtak GCM2_E2F8 ATrsGGGtwatsGcGGGAaw GCM2_ELK1 rTryGGGCGGAAGTr GCM2_EOMES rTGCGGGhagGTGtga GCM2_FIGLA_1 aTrCGGGtmCAssTG GCM2_FIGLA_2 mCAssTGkdwyswbkATGCGGG GCM2_FOXI1_1 rTAAATAmGGGya GCM2_FOXI1_2 TrTTkATrcGGGy GCM2_HES7 rTrckGGyryggCACGyGyc GCM2_HOXA13 ATRCGGGTaATAAAa GCM2_MAX aTGcgGGyraCAyGTG GCM2_ONECUT2 ATrcGGGyaawmrATCrATa GCM2_PITX1_1 rTrcgGGyGGATTA GCM2_PITX1_2 rTrcGGGsGATTAr GCM2_SOX15_1 aTrcGGGywykyyywTTGTtk GCM2_SOX15_2 aTrcGGGydwwttyyaTTGTyt GCM2_SOX15_2_3 ATRcGGGywbraaACAAwr GCM2_SOX15_2_3_4 aTRcGGGygaaaACAATr GCM2_TBX21_1 aGGTGTcrwGsGGGy GCM2_TBX21_2 ATGmGGGCTAGGTGtGA GCM2_TEF rTrsGGGykgrTTAyRTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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