DNA Binding Motif

						

			
Accessions: GCM2_TBX21_1 (HumanTF2 1.0), UN0555.1 (JASPAR 2024)

			
Names: GCM2_TBX21, GCM2::TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: aGGTGTcrwGsGGGy
Weblogo: 
PSSM: P0      A      C      G      T
01   4220    244    723   1207      a
02    553    152   4220    805      G
03     86      0   4220      0      G
04      0     33    351   4220      T
05    233     18   4220      0      G
06    731     87    439   4220      T
07    325   2552    959    384      c
08   2600     35   1556     29      r
09   1768     25     11   2416      w
10   1077    173   4220     65      G
11    583   1842   2379    653      s
12    124     47   4220    227      G
13     23      7   4220     40      G
14    225     31   4220     39      G
15    640   1076    461   2043      y
Type: Heterodimer
Binding TFs: GCM2_TF1 (GCM motif protein)
TBX21_TF2 (T-box)
Q9UL17 (T-box)
Q9UL17
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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