Transcription Factor
| Accessions: | MAX_Full (HumanTF2 1.0) |
| Names: | CSAID-binding protein, CSBP, Cytokine suppressive anti-inflammatory drug-binding protein, EC 2.7.11.24, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAPK 14, MAX, MAX-interacting protein 2, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, MK14_HUMAN, SAPK2a, Stress-activated protein kinase 2a |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q16539 |
| Notes: | Ensembl ID: ENSG00000125952; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: bHLH; Clone source: Jolma et al. 2013 |
| Length: | 161 |
| Pfam Domains: | 24-74 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR 60 61 AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN 120 121 SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS* |
| Interface Residues: | 25, 27, 28, 29, 31, 32, 35, 36, 40, 60 |
| 3D-footprint Homologues: | 7z5k_B, 1a0a_B, 1an4_A, 7rcu_E, 5gnj_I, 6g1l_A, 1am9_A, 7ssa_L, 5i50_B, 8osl_O, 7d8t_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 7xq5_A, 5v0l_A |
| Binding Motifs: | ERF_MAX aCCGGAAaCACGTGs FLI1_MAX accGGAAaCACGTGg GCM1_MAX_1 rbCACGTGsrTGckGGyr GCM1_MAX_2 rgCACGTGkkyvsgggcgrTGCGGGyrs GCM1_MAX_2_3 aTGCGGGyrgsgmgCACGTGg GCM1_MAX_2_3_4 CACGTGgwTgcgGGy GCM1_MAX_2_3_4_5 rgCACGTGsyyrvkggssrTGCGGGTrs GCM1_MAX_2_3_4_5_6 aTGCGGGyrggrrgCACGTGs GCM2_MAX aTGcgGGyraCAyGTG MEIS1_MAX wTGACrbgtsrvCACGTGc MYBL1_MAX_1 sCACGTGcyyAACsgyy MYBL1_MAX_2 yAACskhhryvtggagCACGTG MYBL1_MAX_2_3 yAACsgymgwvgcrrrsCACGTG TEAD4_MAX_1 GGwATGyrCACGTG TEAD4_MAX_2 rCATwCCdhmrrsCACGTG TEAD4_MAX_2_3 rmATwCCwcwhravCACGTG TFAP2C_MAX_1 trsCCysrGGsgrkCACGTGs TFAP2C_MAX_2 trsCCysrGGssrwrCACGTGs TFAP2C_MAX_2_3 tgsCCysrGGssawrbsssssrrsCACGTGs TFAP2C_MAX_2_3_4 tgsCCysrGGssayrysssvssrrsCACGTG TFAP4_MAX_1 yCAGCTGrmvrsCACGTGs TFAP4_MAX_2 dCAGCTGwbmrgmgCACGTGs TFAP4_MAX_2_3 wCAsCTGdtbssCACGTGs |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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