DNA Binding Motif

						

			
Accessions: TFAP4_MAX_2_3 (HumanTF2 1.0)

			
Names: TFAP4_MAX
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; PWM is from validation experiment performed with full-length TFs and is not included into the dendrograms
Length: 19
Consensus: wCAsCTGdtbssCACGTGs
Weblogo: 
PSSM: P0      A      C      G      T
01    258    217     82    365      w
02      9    923     23     31      C
03    923     23     26      0      A
04     13    599    923     28      s
05     48    923    253     14      C
06     38      4     37    923      T
07     39     49    923     10      G
08    291     84    254    293      d
09    156    210    202    355      t
10    174    272    232    245      b
11    211    243    274    195      s
12    178    288    349    108      s
13     39    923     11      0      C
14    923      0    125     33      A
15      0    923      0     58      C
16    137      0    923      0      G
17      0    148     16    923      T
18     18      0    923     59      G
19    162    311    255    195      s
Type: Heterodimer
Binding TFs: MAX_TF2 (Helix-loop-helix DNA-binding domain)
TFAP4_TF1 (Helix-loop-helix DNA-binding domain)
TFAP4_Full (Helix-loop-helix DNA-binding domain)
MAX_Full (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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