Transcription Factor

						

			
Accessions: TFAP4_full (HumanTF 1.0), TFAP4_Full (HumanTF2 1.0)

			
Names: Q6FHM5_HUMAN, TFAP4
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: Q6FHM5
Notes: Ensembl ID: ENSG00000090447; Full protein sequence; TF family: bHLH; Clone source: hORFeome, Ensembl ID: ENSG00000090447; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: bHLH; Clone source: Jolma et al. 2013
Length: 339
Pfam Domains:    49-100 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MEYFMVPTQKVPSLQHFRKTEKEVIGGLCSLANIPLTPETQRDQERRIRREIANSNERRR   60
  61 MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQEL  120
 121 SGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLE  180
 181 AHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAP  240
 241 PPPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKP  300
 301 VRSCPEAPTSDTASDSEASDSDAMDQSREEPSGDGELP*
Interface Residues: 50, 52, 53, 54, 56, 57, 60, 61, 85
3D-footprint Homologues: 2ypa_A, 7z5k_B, 1an4_A, 5i50_B, 5eyo_A, 1am9_A, 2ypa_B, 2ql2_A, 7d8t_A, 2ql2_D, 7ssa_L, 6g1l_A, 5gnj_I
Binding Motifs: TFAP4_full AwCAGCTGwT
TFAP4_DLX3_1 kCAGsTGdvggrsgyaATkr
TFAP4_DLX3_2 yCAGsTGkdbgkrsgtaATtr
TFAP4_DLX3_2_3 AwCAGCTGATywTAATtr
TFAP4_DLX3_2_3_4 AwCAGCTGwTysssgYaatkr
TFAP4_ETV1 rsCGGAwgCAGsTGgk
TFAP4_ETV4 rsCGGAwvCAgsTGkb
TFAP4_FLI1_1 rscGGAwrCAgsTGg
TFAP4_FLI1_2 acCGGAAACAGCTGwy
TFAP4_MAX_1 yCAGCTGrmvrsCACGTGs
TFAP4_MAX_2 dCAGCTGwbmrgmgCACGTGs
TFAP4_MAX_2_3 wCAsCTGdtbssCACGTGs
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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