DNA Binding Motif

						

			
Accessions: TFAP4_DLX3_2_3_4 (HumanTF2 1.0)

			
Names: TFAP4_DLX3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; PWM is from validation experiment performed with full-length TFs and is not included into the dendrograms
Length: 21
Consensus: AwCAGCTGwTysssgYaatkr
Weblogo: 
PSSM: P0      A      C      G      T
01    493      0     22      0      A
02    188      0      0    351      w
03      0    487      0      0      C
04    487      0      0      0      A
05      0      0    487      0      G
06      0    487      0      0      C
07      0      0      0    487      T
08      2      4    487      0      G
09    343      0     19    163      w
10      0     12      0    523      T
11     64    212     89    122      y
12    119    125    187     56      s
13     95    145    194     53      s
14     44    185    182     75      s
15    110    110    189     78      g
16      0    219      0    487      Y
17    487    179    143     80      a
18    487    143    115      0      a
19     75    175    203    487      t
20     69    145    245    487      k
21    298      9    177      2      r
Type: Heterodimer
Binding TFs: DLX3_TF2 (Homeobox domain)
TFAP4_TF1 (Helix-loop-helix DNA-binding domain)
TFAP4_Full (Helix-loop-helix DNA-binding domain)
DLX3_Crystal (Homeobox domain)
DLX3_Full (Homeobox domain, Homeobox protein distal-less-like N terminal )
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.