DNA Binding Motif

						

			
Accessions: TFAP4_ETV1 (HumanTF2 1.0), MA1966.1 (JASPAR 2024)

			
Names: TFAP4_ETV1, TFAP4::ETV1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rsCGGAwgCAGsTGgk
Weblogo: 
PSSM: P0      A      C      G      T
01   1408    281   1517    436      r
02    310   1541   1384    176      s
03    498   2925    183    101      C
04     34     22   2925     32      G
05     41     51   2925     64      G
06   2925     59    124     71      A
07   2925     82    145   1346      w
08    706    359   1821     39      g
09     20   2925     16    117      C
10   2925     63    323     99      A
11     80    572   2925    491      G
12    722   1443   1482    107      s
13    127    316    188   2925      T
14     17     23   2925     88      G
15    541    371   1315    698      g
16    521    637    960    808      k
Type: Heterodimer
Binding TFs: ETV1_TF2 (Ets-domain)
TFAP4_TF1 (Helix-loop-helix DNA-binding domain)
TFAP4_Full (Helix-loop-helix DNA-binding domain)
Q01664 (Helix-loop-helix DNA-binding domain)
Q01664
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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