DNA Binding Motif

						

			
Accessions: TFAP4_FLI1_2 (HumanTF2 1.0), MA1967.1 (JASPAR 2024)

			
Names: TFAP4_FLI1, TFAP4::FLI1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; PWM is from validation experiment performed with full-length TFs and is not included into the dendrograms, HT-SELEX
Length: 16
Consensus: acCGGAAACAGCTGwy
Weblogo: 
PSSM: P0      A      C      G      T
01   1076    114    350    103      a
02    200   1076    365     47      c
03    175   1076     50     12      C
04      0     54   1076     14      G
05     53    104   1076     91      G
06   1076     21     15     21      A
07   1076     11      0    149      A
08   1076     23    169     25      A
09      0   1076      0      0      C
10   1076      0      1      1      A
11      0      8   1076      0      G
12      0   1076     15      0      C
13      0      0      0   1076      T
14      0      0   1076      0      G
15    347    126    259    345      w
16    211    277    160    428      y
Type: Heterodimer
Binding TFs: FLI1_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_Full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
TFAP4_TF1 (Helix-loop-helix DNA-binding domain)
TFAP4_Full (Helix-loop-helix DNA-binding domain)
Q01664 (Helix-loop-helix DNA-binding domain)
Q01664
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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