DNA Binding Motif

						

			
Accessions: TFAP4_DLX3_2_3 (HumanTF2 1.0)

			
Names: TFAP4_DLX3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; PWM is from validation experiment performed with full-length TFs and is not included into the dendrograms
Length: 18
Consensus: AwCAGCTGATywTAATtr
Weblogo: 
PSSM: P0      A      C      G      T
01   1175     76    319      0      A
02    547     98      0    978      w
03      0   1568      0      0      C
04   1568      0      0      0      A
05      0      0   1568      0      G
06      0   1568      0      0      C
07      0      0      0   1568      T
08      5      0   1568      0      G
09   1100      0    121    379      A
10     18    261      6   1283      T
11    262    474    224    608      y
12    427    204    382    556      w
13     57    301    203   1568      T
14   1568    323    324     43      A
15   1568    204    282      0      A
16     25    280    367   1568      T
17     92    175    386   1182      t
18    655    137    913    116      r
Type: Heterodimer
Binding TFs: DLX3_TF2 (Homeobox domain)
TFAP4_TF1 (Helix-loop-helix DNA-binding domain)
TFAP4_Full (Helix-loop-helix DNA-binding domain)
DLX3_Crystal (Homeobox domain)
DLX3_Full (Homeobox domain, Homeobox protein distal-less-like N terminal )
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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