DNA Binding Motif

						

			
Accessions: TFAP4_full (HumanTF 1.0), MA0691.1 (JASPAR 2024)

			
Names: TFAP4
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: AwCAGCTGwT
Weblogo: 
PSSM: P0      A      C      G      T
01   3423    500    337    228      A
02   2159    546     62   1264      w
03      0   3423      0      0      C
04   3423      2      0      0      A
05      2     85   3423     14      G
06     21   3423     49      6      C
07      1      1      0   3423      T
08      0      1   3423      0      G
09   1810    114    333   1613      w
10    299    682    433   3423      T
Type: Heterodimer
Binding TFs: TFAP4_full (Helix-loop-helix DNA-binding domain)
Q01664 (Helix-loop-helix DNA-binding domain)
Q01664
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Jung P, Menssen A, Mayr D, Hermeking H. AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A 105:15046-51 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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