Transcription Factor

						

			
Accessions: TFAP4_HUMAN (HOCOMOCO 10), Q01664 (JASPAR 2024)

			
Names: Activating enhancer-binding protein 4, bHLHc41, Class C basic helix-loop-helix protein 41, TFAP4_HUMAN, Transcription factor AP-4
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q01664
Length: 338
Pfam Domains:    49-100 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MEYFMVPTQKVPSLQHFRKTEKEVIGGLCSLANIPLTPETQRDQERRIRREIANSNERRR   60
  61 MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQEL  120
 121 SGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLE  180
 181 AHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQLRTQLLPPPAPTHHPTVIVPAP  240
 241 PPPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAIQHIEGTQEKQELEEEQRRAVIVKP  300
 301 VRSCPEAPTSDTASDSEASDSDAMDQSREEPSGDGELP
Interface Residues: 50, 52, 53, 54, 56, 57, 60, 61, 85
3D-footprint Homologues: 2ypa_A, 7z5k_B, 1an4_A, 1am9_A, 5i50_B, 5eyo_A, 2ypa_B, 2ql2_A, 7d8t_A, 2ql2_D, 5gnj_I, 7ssa_L, 6g1l_A
Binding Motifs: MA0691.1 AwCAGCTGwT
MA1966.1 rsCGGAwgCAGsTGgk
MA1967.1 acCGGAAACAGCTGwy
MA1570.1 ahCAyrTGkt
TFAP4_HUMAN.H10MO.C|M01569 ryCAGCTGygG
MA1966.2 sCGGAwgCAGsTG
MA1967.2 acCGGAAACAGCTG
			
Publications: Jung P, Menssen A, Mayr D, Hermeking H. AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A 105:15046-51 (2008). [Pubmed]


Badinga L, Song S, Simmen RC, Simmen FA. A distal regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2) gene interacts with the basic helix-loop-helix transcription factor, AP-4. Endocrine 8:281-9 (1998). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.