DNA Binding Motif

						

			
Accessions: TFAP4_8 (HT-SELEX2 May2017), MA1570.1 (JASPAR 2024)

			
Names: TFAP4, TFAP4(var.2)
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: ahCAyrTGkt
Weblogo: 
PSSM: P0      A      C      G      T
01    479    130    197     39      a
02    217    144      0    129      h
03      0    479      0      0      C
04    479      0     14      0      A
05      0    220    161    479      y
06    479    149    287      0      r
07      0      0      0    479      T
08      0      3    479      0      G
09    103     14    156    206      k
10     60    210    110    479      t
Type: Heterodimer
Binding TFs: TFAP4 (Helix-loop-helix DNA-binding domain)
Q01664 (Helix-loop-helix DNA-binding domain)
Q01664
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Badinga L, Song S, Simmen RC, Simmen FA. A distal regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2) gene interacts with the basic helix-loop-helix transcription factor, AP-4. Endocrine 8:281-9 (1998). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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