DNA Binding Motif

						

			
Accessions: TFAP4_DLX3_2 (HumanTF2 1.0)

			
Names: TFAP4_DLX3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 21
Consensus: yCAGsTGkdbgkrsgtaATtr
Weblogo: 
PSSM: P0      A      C      G      T
01    145    267    168    354      y
02      0    933     12      0      C
03    933     44      3     32      A
04      0     99    933    114      G
05     66    597    337     16      s
06      0     36     16    933      T
07     25      0    933      0      G
08     74    215    341    304      k
09    244    129    322    238      d
10    135    234    316    248      b
11     44    222    490    179      g
12    145    217    337    234      k
13    431    124    251    127      r
14     59    336    456     82      s
15    462    482    933    366      g
16    112    220    152    933      t
17    933     98    337     89      a
18    933     18     33     26      A
19     70     37    166    933      T
20     84    138    256    677      t
21    325     85    608    121      r
Type: Heterodimer
Binding TFs: DLX3_TF2 (Homeobox domain)
TFAP4_TF1 (Helix-loop-helix DNA-binding domain)
TFAP4_Full (Helix-loop-helix DNA-binding domain)
DLX3_Crystal (Homeobox domain)
DLX3_Full (Homeobox domain, Homeobox protein distal-less-like N terminal )
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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