Transcription Factor
| Accessions: | MAX_DBD (HumanTF 1.0), MAX_TF2 (HumanTF2 1.0), MAX (HT-SELEX2 May2017) |
| Names: | MAD1_HUMAN, MAX, Max dimerization protein 1, Max dimerizer 1, Protein MAD, CSAID-binding protein, CSBP, Cytokine suppressive anti-inflammatory drug-binding protein, EC 2.7.11.24, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAPK 14, MAX-interacting protein 2, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, MK14_HUMAN, SAPK2a, Stress-activated protein kinase 2a, ENSG00000125952 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q05195 |
| Notes: | Ensembl ID: ENSG00000125952; DNA-binding domain sequence; TF family: bHLH; Clone source: Megaman, Ensembl ID: ENSG00000125952; Construct type: TF2(3xFLAG); TF family: bHLH; Clone source: Jolma et al. 2013, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 117 |
| Pfam Domains: | 22-72 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 DNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQ 60 61 ILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSD |
| Interface Residues: | 23, 25, 26, 27, 29, 30, 33, 34, 38, 58 |
| 3D-footprint Homologues: | 1a0a_B, 7z5k_B, 1an4_A, 6g1l_A, 4h10_B, 7ssa_L, 5i50_B, 1am9_A, 8osl_O, 7d8t_A, 4zpk_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 7xq5_A, 5v0l_A, 4h10_A, 7rcu_E, 5gnj_I |
| Binding Motifs: | MAX_DBD_1 CACGTGsymamCACGTG MAX_DBD_2 amCACGTGcy ERF_MAX aCCGGAAaCACGTGs FLI1_MAX accGGAAaCACGTGg GCM1_MAX_1 rbCACGTGsrTGckGGyr GCM1_MAX_2 rgCACGTGkkyvsgggcgrTGCGGGyrs GCM1_MAX_2_3 aTGCGGGyrgsgmgCACGTGg GCM1_MAX_2_3_4 CACGTGgwTgcgGGy GCM1_MAX_2_3_4_5 rgCACGTGsyyrvkggssrTGCGGGTrs GCM1_MAX_2_3_4_5_6 aTGCGGGyrggrrgCACGTGs GCM2_MAX aTGcgGGyraCAyGTG MEIS1_MAX wTGACrbgtsrvCACGTGc MYBL1_MAX_1 sCACGTGcyyAACsgyy MYBL1_MAX_2 yAACskhhryvtggagCACGTG MYBL1_MAX_2_3 yAACsgymgwvgcrrrsCACGTG TEAD4_MAX_1 GGwATGyrCACGTG TEAD4_MAX_2 rCATwCCdhmrrsCACGTG TEAD4_MAX_2_3 rmATwCCwcwhravCACGTG TFAP2C_MAX_1 trsCCysrGGsgrkCACGTGs TFAP2C_MAX_2 trsCCysrGGssrwrCACGTGs TFAP2C_MAX_2_3 tgsCCysrGGssawrbsssssrrsCACGTGs TFAP2C_MAX_2_3_4 tgsCCysrGGssayrysssvssrrsCACGTG TFAP4_MAX_1 yCAGCTGrmvrsCACGTGs TFAP4_MAX_2 dCAGCTGwbmrgmgCACGTGs TFAP4_MAX_2_3 wCAsCTGdtbssCACGTGs MAX_2 sCACGTGsysrsCACGTGs MAX_4 ryCACGTGyr MAX_methyl_1 mCATGTGmytrmCAYGTGs MAX_methyl_3 rmCAYGTGmt |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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