DNA Binding Motif

						

			
Accessions: FLI1_MAX (HumanTF2 1.0), UN0532.1 (JASPAR 2024)

			
Names: FLI1_MAX, FLI1::MAX
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: accGGAAaCACGTGg
Weblogo: 
PSSM: P0      A      C      G      T
01    277    109    109     98      a
02     79    290     96     27      c
03    141    386     49     16      c
04      8      1    386      0      G
05      8      3    386     16      G
06    386      9      9      5      A
07    386      5      3     70      A
08    246     73     55     12      a
09      0    386     11      7      C
10    386      0     27     19      A
11      0    386     21     42      C
12     53      1    386      2      G
13     17     42      0    386      T
14      2      5    386      7      G
15     66     90    150     81      g
Type: Heterodimer
Binding TFs: Q01543 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_Full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
MAX_TF2 (Helix-loop-helix DNA-binding domain)
MAX_Full (Helix-loop-helix DNA-binding domain)
Q01543
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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