Transcription Factor
| Accessions: | FLI1_full (HumanTF 1.0), FLI1_Full (HumanTF2 1.0) |
| Names: | FLI1, FLI1_HUMAN, Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q01543 |
| Notes: | Ensembl ID: ENSG00000151702; Full protein sequence; TF family: ETS; Clone source: hORFeome, Ensembl ID: ENSG00000151702; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 453 |
| Pfam Domains: | 114-197 Sterile alpha motif (SAM)/Pointed domain 280-362 Ets-domain |
| Sequence: (in bold interface residues) | 1 MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQ 60 61 PVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTN 120 121 ERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATT 180 181 LYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNK 240 241 SPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCI 300 301 TWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF 360 361 DFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAAS 420 421 QYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY* |
| Interface Residues: | 278, 333, 334, 336, 337, 338, 340, 341, 355 |
| 3D-footprint Homologues: | 3zp5_A, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 8ee9_F, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A |
| Binding Motifs: | FLI1_full_1 ACCGGAArTg FLI1_full_2 aCCGGAwATCCGGt FLI1_BHLHA15 wcCGGAAACATATGk FLI1_CEBPB rvCGGAwrTTGCGCAAy FLI1_CEBPD rmmGGAwATTGCGcAAy FLI1_DLX2_1 rsMGGAAryaaTtA FLI1_DLX2_2 rvmGGAArtsvsyaaTtar FLI1_DLX2_2_3 ACCGGAArTgrsyAATTA FLI1_DRGX aCCGGAwGyAATTAt FLI1_ETV7 rsmGGAmGGAtdTCCgsb FLI1_FIGLA rsmGGAwrCAssTGb FLI1_FOXI1_1 GAAAACCGAAAM FLI1_FOXI1_2 rcCGGAWGTTkay FLI1_FOXI1_2_3 rtaAACAGGAwryd FLI1_FOXI1_2_3_4 TGTtkmCGGAwrtg FLI1_HOXB13_1 rccGGAArymrTwAa FLI1_HOXB13_2 ACCGGAAGTCRTAAAa FLI1_MAX accGGAAaCACGTGg FLI1_ONECUT2 acCGGAWryrmtgrTCGAT FLI1_TCF3 rCCGGAwrCAssTgy FOXO1_FLI1 GwmAACAGGAAGTk TEAD4_FLI1 ACCGGAAATrCc TFAP4_FLI1_1 rscGGAwrCAgsTGg TFAP4_FLI1_2 acCGGAAACAGCTGwy |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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