DNA Binding Motif

						

			
Accessions: FLI1_DRGX (HumanTF2 1.0), MA1949.1 (JASPAR 2024)

			
Names: FLI1_DRGX, FLI1::DRGX
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: aCCGGAwGyAATTAt
Weblogo: 
PSSM: P0      A      C      G      T
01    239     29     81     69      a
02     39    291     40     48      C
03    106    418     11      2      C
04      1      0    418      1      G
05     10      0    418     12      G
06    418      4      0      0      A
07    287      0     14    130      w
08     68     65    418     37      G
09      8    137     13    281      y
10    343     75     35     44      A
11    418     15     93     30      A
12      5     38     50    418      T
13     41    103     23    418      T
14    418     59     61     53      A
15     80     53     88    196      t
Type: Heterodimer
Binding TFs: Q01543 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
DRGX_TF2 (Homeobox domain)
FLI1_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_Full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
Q01543
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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