DNA Binding Motif

						

			
Accessions: FLI1_BHLHA15 (HumanTF2 1.0), UN0525.1 (JASPAR 2024)

			
Names: FLI1_BHLHA15, FLI1::BHLHA15
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: wcCGGAAACATATGk
Weblogo: 
PSSM: P0      A      C      G      T
01     30      9     18     20      w
02     18     76     21      3      c
03     22     76      7      2      C
04      2      0     76      0      G
05      2      0     76      1      G
06     76      3      0      2      A
07     76      0      0     10      A
08     53      9     14      0      A
09      1     76      1      5      C
10     76      2     10      3      A
11      3      2      9     76      T
12     76      6      5      3      A
13      9      4      1     76      T
14      5      3     76      8      G
15      0      6     35     35      k
Type: Heterodimer
Binding TFs: BHLHA15_TF2 (Helix-loop-helix DNA-binding domain)
FLI1_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_Full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
Q7RTS1 (Helix-loop-helix DNA-binding domain)
Q7RTS1
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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