DNA Binding Motif

						

			
Accessions: FLI1_FIGLA (HumanTF2 1.0), UN0529.1 (JASPAR 2024)

			
Names: FLI1_FIGLA, FLI1::FIGLA
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: rsmGGAwrCAssTGb
Weblogo: 
PSSM: P0      A      C      G      T
01   1901    685   1327    781      r
02    555   2192   1036    227      s
03   1216   3228    279     48      m
04     13      8   3228     11      G
05      7     14   3228     33      G
06   3228     23     13     33      A
07   3228    185     40   1382      w
08   1560    618    987     63      r
09     19   3228      0     17      C
10   3228     26     76      0      A
11     26   1448   1780     59      s
12    114   2076   1152     26      s
13     24    177     47   3228      T
14     33     20   3228     85      G
15    435    844   1111    838      b
Type: Heterodimer
Binding TFs: FIGLA_TF2 (Helix-loop-helix DNA-binding domain)
FLI1_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_Full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
Q6QHK4 (Helix-loop-helix DNA-binding domain)
Q6QHK4
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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