DNA Binding Motif

						

			
Accessions: FOXO1_FLI1 (HumanTF2 1.0), MA1956.1 (JASPAR 2024)

			
Names: FOXO1_FLI1, FOXO1::FLI1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: GwmAACAGGAAGTk
Weblogo: 
PSSM: P0      A      C      G      T
01     39     16    169      0      G
02    100     57     15    208      w
03    142     65      0      4      m
04    208      5      0      0      A
05    208      0      0      6      A
06      0    208      0      3      C
07    208     10      1      0      A
08     12      4    208      0      G
09      8      0    208      1      G
10    208      0      0      1      A
11    208      4      0     34      A
12     47     12    208      0      G
13      5     44     16    208      T
14     27     21     93     67      k
Type: Heterodimer
Binding TFs: FLI1_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FLI1_Full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
FOXO1_TF1 / FOXO1_TF2 (Fork head domain)
Q12778 (Fork head domain)
Q12778
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB. Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions. Nat Commun 11:124 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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