footprintDB - a database of transcription factors with annotated cis elements (DNA motifs and sites) and binding interfaces

Database 'UniPROBE 20160601' (Transcription Factors 601-650)

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Accessions	Names	Organisms	Description and notes
UP00583A	TGME49_306620, TGME49_306620 AP2IX-9	Toxoplasma gondii	TGME49_306620 AP2IX-9: AP2 domain transcription factor AP2IX-9
UP00511A	CG7895, Dmel\CG7895, DmNK-4, DROHOXHK4, DROHOXNK4, msh-2, msh2, Muscle-specific homeobox protein NK-4/msh-2, NK4/msh-2, Tin, tin/NK4, Tinman	Drosophila melanogaster	Tinman: Tinman is required for the development of heart and muscle and for the formation of somatic muscles and has crucial function in the early mesodermal subdivisions.
UP00165A	AV026640, Homeobox protein Nkx-2.1, Nkx2-1, Nkx2.1, T/EBP, Thyroid nuclear factor thyroid transcription factor 1, thyroid-specific enhancer-binding protein, tinman, Titf1, Ttf-1, Ttf1	Mus musculus	thyroid transcription factor 1
UP00244A	Enx, homeobox 2, Homeobox protein Hox-11L1, Homeobox TLX-2, Hox11L.1, Hox11l1, Ncx1, PMUR10F, T-cell leukemia, T-cell leukemia homeobox protein 2, Tlx1l1, Tlx1l2, Tlx2	Mus musculus	T-cell leukemia, homeobox 2
UP00324A	Basic-helix-loop-helix protein SGC1, O6233, Serine-rich protein TYE7, Tye7, YOR344C	Saccharomyces cerevisiae	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator
UP00512A	abx, BX-C, bx[D], bxd, bxd[D], bxl, Cbx, CG10388, Dm Ubx, DmUbx, DUbx, Hm, Homeotic protein ultrabithorax, l(3)89Eb, pbx, Uab, Ubx, Ubx1b, Ultrabithorax	Drosophila melanogaster	Ultrabithorax: Ubx is a sequence-specific transcription factor which is part a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.
UP00334A	CAR80, CARGR1, Negative transcriptional regulator of IME2, NIM2, RIM16, Transcriptional UME6, Ume6, YD8142.04C, YDR207C	Saccharomyces cerevisiae	Key transcriptional regulator of early meiotic genes, binds URS1 upstream sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms comp...
UP00142A	Not Available, Unc4.1 homeobox (C. elegans), Uncx4.1	Mus musculus	Unc4.1 homeobox (C. elegans)
UP00470A	MOX4, Upc2, UPtake Control	Saccharomyces cerevisiae	UPtake Control : Sterol regulatory element binding protein, induces transcription sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion
UP00343A	Not Available, Usv1	Saccharomyces cerevisiae	Putative transcription factor containing a C2H2 zinc finger; mutation affects regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
UP00215A	Not Available, Vax1, ventral anterior homeobox containing gene 1	Mus musculus	ventral anterior homeobox containing gene 1
UP00106A	Vax2, Ventral anterior homeobox 2, ventral anterior homeobox containing gene Ventral retina homeodomain protein, Vex	Mus musculus	ventral anterior homeobox containing gene 2
UP00623B	DRES93, VAX2_L139M, ventral anterior homeobox 2	Homo sapiens	ventral anterior homeobox 2: Transcription factor that may function in specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.
UP00623A	DRES93, VAX2_REF, ventral anterior homeobox 2	Homo sapiens	ventral anterior homeobox 2: Transcription factor that may function in specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.
UP00624B	homeobox protein VENTX, HPX42B, MGC119910, MGC119911, NA88A, VENT homeobox homolog, homeobox protein 2, VENTX_E101K, VENTX2	Homo sapiens	homeobox protein VENTX: This gene encodes a member of the family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]
UP00624C	homeobox protein VENTX, HPX42B, MGC119910, MGC119911, NA88A, VENT homeobox homolog, homeobox protein 2, VENTX_R143C, VENTX2	Homo sapiens	homeobox protein VENTX: This gene encodes a member of the family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]
UP00624A	homeobox protein VENTX, HPX42B, MGC119910, MGC119911, NA88A, VENT homeobox homolog, homeobox protein 2, VENTX_REF, VENTX2	Homo sapiens	homeobox protein VENTX: This gene encodes a member of the family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]
UP00471A	Vhr1, VHt1 Regulator	Saccharomyces cerevisiae	VHt1 Regulator : Transcriptional activator, required for the vitamin H-responsive (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
UP00472A	Vhr2, VHt1 Regulator	Saccharomyces cerevisiae	VHt1 Regulator : Non-essential nuclear protein; null mutation has global on transcription
UP00579A	ANAC105, Arabidopsis NAC domain containing protein 105, K1L20_8, K1L20.8, NAC containing protein, VASCULAR-RELATED NAC-DOMAIN 3, VND3	Arabidopsis thaliana	NAC domain containing protein: Transcription activator that binds to the wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, ge
UP00580A	ANAC030, Arabidopsis NAC domain containing protein 30, ARABIDOPSIS NAC-DOMAIN PROTEIN F17M19_8, F17M19.8, vascular related NAC-domain protein 7, VND7	Arabidopsis thaliana	vascular related NAC-domain protein 7: Transcription activator that binds to secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating pro
UP00581A	vascular plant one zinc finger protein 2, VOZ2	Arabidopsis thaliana	vascular plant one zinc finger protein 2: Transcriptional activator acting in the phytochrome B signaling pathway. Functions redundantly with VOZ1 to promote flowering downstream of phytochrome B (phyB). Down-regulates 'FLOWERING LOCUS C' (FLC) and up-regulates 'FLOWERING LOCUS T' (FT). Binds to the 38-bp cis-acting region of the AVP1 gene. Binds as a dimer to the palindromic sequence 5'-GCGTNNNNNNNACGC
UP00141A	Homeodomain protein RINX, Retinal inner nuclear layer homeobox protein, Transcription VSX1, visual system homeobox 1 homolog (zebrafish), Vsx1	Mus musculus	visual system homeobox 1 homolog (zebrafish)
UP00625B	Homeodomain protein RINX, KTCN, PPCD, PPD, Retinal inner nuclear layer protein, Transcription factor VSX1, visual system homeobox 1, VSX1_G160D	Homo sapiens	visual system homeobox 1: The protein encoded by this gene a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UP00625C	Homeodomain protein RINX, KTCN, PPCD, PPD, Retinal inner nuclear layer protein, Transcription factor VSX1, visual system homeobox 1, VSX1_Q175H	Homo sapiens	visual system homeobox 1: The protein encoded by this gene a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UP00625D	Homeodomain protein RINX, KTCN, PPCD, PPD, Retinal inner nuclear layer protein, Transcription factor VSX1, visual system homeobox 1, VSX1_R166Q	Homo sapiens	visual system homeobox 1: The protein encoded by this gene a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UP00625A	Homeodomain protein RINX, KTCN, PPCD, PPD, Retinal inner nuclear layer protein, Transcription factor VSX1, visual system homeobox 1, VSX1_REF	Homo sapiens	visual system homeobox 1: The protein encoded by this gene a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UP00626B	Ceh-10 homeodomain-containing homolog, CHX10, Homeobox protein CHX10, HOX10, MCOP2, MCOPCB3, visual system homeobox 2, VSX2_R200P	Homo sapiens	visual system homeobox 2: This gene encodes a homeobox protein described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).
UP00626C	Ceh-10 homeodomain-containing homolog, CHX10, Homeobox protein CHX10, HOX10, MCOP2, MCOPCB3, visual system homeobox 2, VSX2_R200Q	Homo sapiens	visual system homeobox 2: This gene encodes a homeobox protein described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).
UP00626A	Ceh-10 homeodomain-containing homolog, CHX10, Homeobox protein CHX10, HOX10, MCOP2, MCOPCB3, visual system homeobox 2, VSX2_REF	Homo sapiens	visual system homeobox 2: This gene encodes a homeobox protein described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).
UP00582A	ARABIDOPSIS THALIANA WRKY DNA-BINDING PROTEIN 18, At4g31800, AtWRKY18, F11C18.16, F28M20.10, transcription factor 1, WRKY transcription factor 18, WRKY1	Arabidopsis thaliana	WRKY transcription factor 1: Transcription factor. Binds to a 5'-CGTTGACCGAG-3' core sequence which contains a W box, a frequently occurring elicitor-responsive cis-acting element.
UP00627B	AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_F392L, WT33	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues.
UP00627C	AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_H373Y, WT33	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues.
UP00627D	AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_R366C, WT33	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues.
UP00627E	AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_R366L, WT33	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues.
UP00627F	AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_R394L, WT33	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues.
UP00627G	AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_R394W, WT33	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues.
UP00627A	AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_REF, WT33	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues.
UP00330A	Transcriptional repressor XBP1, Xbp1, XhoI site-binding protein 1, YIL101C	Saccharomyces cerevisiae	Transcriptional repressor that binds to promoter sequences of the cyclin CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4...
UP00327A	AP-1-like transcription factor YAP1, PAR1, PDR4, Phenanthroline resistance protein PAR1, drug resistance protein PDR4, SNQ3, Yap1, YM9571.12, YML007W	Saccharomyces cerevisiae	Basic leucine zipper (bZIP) transcription factor required for oxidative stress mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxi...
UP00473A	Yap3, Yeast AP-1	Saccharomyces cerevisiae	Yeast AP-1: Basic leucine zipper (bZIP) transcription factor
UP00316A	AP-1-like transcription factor YAP6, HAL7, Yap6, YD9320A.09C, YD9320A.10C, YDR259C	Saccharomyces cerevisiae	Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium lithium tolerance
UP00474A	Expression Dependent on Slt2, Ybr033w	Saccharomyces cerevisiae	Expression Dependent on Slt2 : Putative zinc cluster protein, predicted be a transcription factor; YBR033W is not an essential gene
UP00331A	Putative 60.3 kDa transcriptional regulatory protein in PRP5-THI2 intergenic region, Ybr239c	Saccharomyces cerevisiae	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein to the cytoplasm and nucleus; YBR239C is not an essential gene
UP00323A	Not Available, Ydr520c	Saccharomyces cerevisiae	Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine
UP00284A	Putative 50.3 kDa zinc finger protein in PAK1-RPS26B intergenic region,	Saccharomyces cerevisiae	Hypothetical protein
UP00475A	Yer184c	Saccharomyces cerevisiae	Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, prevents growth on glycerol or lactate as sole carbon source
UP00293A	Putative 91.0 kDa zinc finger protein in SPT4-ROM1 intergenic region,	Saccharomyces cerevisiae	Putative protein of unknown function; contains a zinc finger motif to that of Adr1p
UP00281A	Putative 82.2 kDa transcriptional regulatory protein in FRE2 5'region, Ykl222c	Saccharomyces cerevisiae	Putative protein of unknown function; similar to transcriptional regulators from zinc cluster (binuclear cluster) protein family; null mutant is sensitive to caffeine
UP00283A	Not Available, Yll054c	Saccharomyces cerevisiae	Putative protein of unknown function with similarity to Pip2p, an transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene

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