Transcription Factor
| Accessions: | UP00165A (UniPROBE 20160601) |
| Names: | AV026640, Homeobox protein Nkx-2.1, Nkx2-1, Nkx2.1, T/EBP, Thyroid nuclear factor 1, thyroid transcription factor 1, thyroid-specific enhancer-binding protein, tinman, Titf1, Ttf-1, Ttf1 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P50220 |
| Description: | thyroid transcription factor 1 |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 LGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQV 60 61 KIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGA |
| Interface Residues: | 11, 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73, 83, 86 |
| 3D-footprint Homologues: | 6m3d_C, 4j19_B, 1puf_A, 1ig7_A, 3d1n_M, 1mnm_C, 5zfz_A, 1zq3_P, 1fjl_B, 6a8r_A, 3cmy_A, 1nk2_P, 2lkx_A, 6es3_K, 2ld5_A, 7q3o_C, 1b72_A, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 7psx_B, 1jgg_B, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 2h1k_B, 1au7_A, 5hod_A, 3lnq_A, 2hdd_A, 5jlw_D, 2xsd_C, 1e3o_C, 7xrc_C, 1le8_A, 8g87_X, 1du0_A, 4cyc_A, 6fqp_B, 1k61_B, 6fqq_E, 1o4x_A, 4qtr_D |
| Binding Motifs: | UP00165A_1 yaAgCCACTTgAmhtt |
| Binding Sites: | AAGTACTC AAGTACTT ACCACTTA ATAAGTGG CACTTAAA CACTTAAG CACTTGAA CACTTGAC CACTTGAG CCACTCAA CCACTCGA CCACTTAA CCACTTCA CCCACTTA CTCAAGTA GCACTTCA GCACTTGA GTACTTCA GTACTTGA TACTTGAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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