Transcription Factor
| Accessions: | UP00626B (UniPROBE 20160601) |
| Names: | Ceh-10 homeodomain-containing homolog, CHX10, Homeobox protein CHX10, HOX10, MCOP2, MCOPCB3, RET1, visual system homeobox 2, VSX2_R200P |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | visual system homeobox 2: This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity). |
| Length: | 90 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 RKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRI 60 61 QVWFQNRPAKWRKREKCWGRSSVMAEYGLY |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73, 74 |
| 3D-footprint Homologues: | 3cmy_A, 2h1k_B, 1ig7_A, 5zfz_A, 1puf_A, 3d1n_M, 6a8r_A, 1fjl_B, 2lkx_A, 6m3d_C, 1jgg_B, 1nk2_P, 1zq3_P, 3lnq_A, 7q3o_C, 2ld5_A, 6es3_K, 3rkq_B, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 7psx_B, 5hod_A, 2hos_A, 1au7_A, 3a01_E, 5jlw_D, 1b72_A, 4xrs_G, 1e3o_C, 1du0_A, 1puf_B, 3l1p_A, 4qtr_D, 1o4x_A |
| Binding Motifs: | UP00626B_1 ygwwwhwttTwATATagwaawaw |
| Binding Sites: | ATTATAAT AAATATAT AAATATTT AATTAATA ATATATAG ATATTAAA TATATATA TGTATACA TTGTACAA AAATGAAA AGAACAAA AGAATAAA ATAAGAAA ATATAAGA ATATTTAA ATTTACAA CATGATTA GTTTAAAC TAATACTA TACTACTA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.