Transcription Factor
| Accessions: | UP00511A (UniPROBE 20160601) |
| Names: | CG7895, Dmel\CG7895, DmNK-4, DROHOXHK4, DROHOXNK4, msh-2, msh2, Muscle-specific homeobox protein tinman, NK-4/msh-2, NK4/msh-2, Tin, tin/NK4, Tinman |
| Organisms: | Drosophila melanogaster |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Tinman: Tinman is required for the development of heart and visceral muscle and for the formation of somatic muscles and has crucial function in the early mesodermal subdivisions. |
| Length: | 142 |
| Pfam Domains: | 28-84 Homeobox domain |
| Sequence: (in bold interface residues) | 1 RSELRKNSISGNSNPGSNSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREII 60 61 AQKLNLSATQVKIWFQNRRYKSKRGDIDCEGIAKHLKLKSEPLDSPTSLPPPIPNHVMWP 120 121 PTMQQSQQQQQHHAQQQQMQHM |
| Interface Residues: | 28, 29, 30, 31, 69, 70, 72, 73, 76, 77, 80, 81, 84 |
| 3D-footprint Homologues: | 3d1n_M, 5zjt_E, 6a8r_A, 2h1k_B, 1puf_A, 1fjl_B, 3cmy_A, 5zfz_A, 1ig7_A, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 2hos_A, 4cyc_A, 1jgg_B, 7psx_B, 3a01_E, 4xrs_G, 2hdd_A, 1b72_A, 3rkq_B, 2r5y_A, 6m3d_C, 5flv_I, 5jlw_D, 2xsd_C, 1e3o_C, 1au7_A, 1le8_A, 7xrc_C, 8g87_X, 1du0_A, 5hod_A, 3l1p_A, 1o4x_A, 4qtr_D, 1k61_B, 1puf_B |
| Binding Motifs: | UP00511A_1 aagrcwtawCCACTTAwrwwymA |
| Binding Sites: | ACACTTGA ACCACTTA ATAAGTGG CACTTAAA CACTTAAG CACTTGAA CACTTGAG CCACTTAA CCACTTAG CCACTTGA CTCAAGTA GCACTTAA GCACTTGA GCCACTTA GGTACTTA GTACTTAA GTACTTGA TAAGTGGA ACAAGTGG ATACTTGA |
| Publications: | Busser BW, Shokri L, Jaeger SA, Gisselbrecht SS, Singhania A, Berger MF, Zhou B, Bulyk ML, Michelson AM. Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity. Development 139:1164-74 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.