Transcription Factor
| Accessions: | UP00511A (UniPROBE 20160601) |
| Names: | CG7895, Dmel\CG7895, DmNK-4, DROHOXHK4, DROHOXNK4, msh-2, msh2, Muscle-specific homeobox protein tinman, NK-4/msh-2, NK4/msh-2, Tin, tin/NK4, Tinman |
| Organisms: | Drosophila melanogaster |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Tinman: Tinman is required for the development of heart and visceral muscle and for the formation of somatic muscles and has crucial function in the early mesodermal subdivisions. |
| Length: | 142 |
| Pfam Domains: | 28-84 Homeobox domain |
| Sequence: (in bold interface residues) | 1 RSELRKNSISGNSNPGSNSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREII 60 61 AQKLNLSATQVKIWFQNRRYKSKRGDIDCEGIAKHLKLKSEPLDSPTSLPPPIPNHVMWP 120 121 PTMQQSQQQQQHHAQQQQMQHM |
| Interface Residues: | 28, 29, 30, 31, 69, 70, 72, 73, 76, 77, 80, 81, 84 |
| 3D-footprint Homologues: | 1ig7_A, 3d1n_M, 5zjt_E, 6a8r_A, 2h1k_B, 1puf_A, 1fjl_B, 3cmy_A, 5zfz_A, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 6m3d_C, 5flv_I, 2hos_A, 4cyc_A, 1jgg_B, 7psx_B, 3a01_E, 4xrs_G, 2hdd_A, 1b72_A, 3rkq_B, 2r5y_A, 5jlw_D, 2xsd_C, 1e3o_C, 1au7_A, 1le8_A, 7xrc_C, 8g87_X, 1du0_A, 5hod_A, 3l1p_A, 1o4x_A, 4qtr_D, 1k61_B, 1puf_B |
| Binding Motifs: | UP00511A_1 aagrcwtawCCACTTAwrwwymA |
| Binding Sites: | ACACTTGA ACCACTTA ATAAGTGG CACTTAAA CACTTAAG CACTTGAA CACTTGAG CCACTTAA CCACTTAG CCACTTGA CTCAAGTA GCACTTAA GCACTTGA GCCACTTA GGTACTTA GTACTTAA GTACTTGA TAAGTGGA ACAAGTGG ATACTTGA |
| Publications: | Busser BW, Shokri L, Jaeger SA, Gisselbrecht SS, Singhania A, Berger MF, Zhou B, Bulyk ML, Michelson AM. Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity. Development 139:1164-74 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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